When your crabs have herpes.
Oh man that dude has a horrid case of derpies.
作者 LIONwho 2011年3月28日
A universal nickname for that really annoying girl that everyone hates. She could be your clingy ex-girlfriend or the girl in your government class that always asks stupid questions. If she's "Derpy" then chances are that everyone you know can find something they hate about her.
"Dude, derpy showed up at my house yesterday, she's so creepy!"

"Are you talking about that blonde chick with the annoying voice? I hate that chick, she gets on my nerves."
作者 thedirtydan 2013年5月17日
Looking slightly retarded in a picture
"She looks so derpy with that duck face!"
"That guy looks so derpy in his pictures."
作者 lilstrudel 2012年2月27日
Derpy - a homicidal rapist usually hailing from Hawaii, often with the intentions of slicing off people's penises and jellifying them for their scorpion overlords.
Baron Von Muffington is such a Derpy!
作者 Boss Nigger. 2012年3月21日
Something that can explain something that is cool or dumb.
1)Man this song is so derpy!
2)Yah, that guy is such a derpy derp!
作者 Rob 2004年6月17日
To be inefficient, slow, unable, inexperienced, not working correctly, stupid, naive, etc. A word that usually takes the place of "retarded."

Can be pertaining to a person or a thing.
I tried to send my essay in via email last night, but my computer was being derpy.

*Friend trips and falls over own feet
You are so derpy sometimes
作者 Derpyhoovs 2011年7月27日

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