Top Definition
A TOTALLY AWESOME LATIN ROCK BAND, LED BY THE GUITARIST OF THE SAME NAME.
There's only one Santana, his first name is Carlos - and he plays the meanest guitar in the world !!
作者 .l 2014年4月28日

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a kickass guitarist that combines blues rock and latin music in one
did Santana ever play with Jimi Hendrix?
i wish it, that would've made someone jizz theirself if they ever heard that song
作者 D money 9295 2010年8月19日

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Santana as in "Saint-Ana". Sanatana means a saint very holy and clean. Originated in spain;
Carlos Santana, guitar player; Juelz Santana aka. DipsEt, rapper.
作者 Jezebel Santana 2007年12月07日

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The most perfect girlfriend you could ever find. Great smile. 10/10. Never let her go because you're definitely going to regret it later in life.
1st girl: Damn is that a Santana with my ex?
2nd girl: Shit, you just lost the ex game.
1st girl: *Starts crying*
作者 Bluebro11 2016年7月28日

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The best friend a girl could have, funny with a great smile. White girl that loves black dick, A LOT. A lady in the streets but a freak in the streets... or backseat of a car.
"who is that girl with that black guy?"
"not sure, she's hot though so she must be a Santana."
作者 666birdhomes 2015年3月28日

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