1. First of all
2. A phrase, used by the intolerably unimaginative, to introduce the first of at least two dull, idiotic points in his/her "argument."
Angry moron #1: First off, buddy, you're way outta line. Second--
Some other guy: Sorry to interrupt, but you're putting me to sleep. I'm gonna go home and take a nap.
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邮件由 email@example.com 发出。我们决不会发送垃圾邮件。