Used when one is happy, sad, excited, etc.
Usually used when one is irritated, however.
It is becoming quite a common occurance in the vocabulary of Western Pennsylvanian school students.
Student 1: "You're such a bitch, Haley."
Student 2: "MEH, Caitrin. Mehhhhh."
Boyfriend: "Melissa, this just isn't working out."
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