'Fuck off' or 'fuck you' in italian. It is a short form for "va' a fare in culo", literally "go to fuck in the ass" (intending "go get fucked in the ass"). Usually considered vulgar, but used often among (young) friends without offending intention. It can be shortened also as simply "fanculo".
A: "Bei capelli stamattina!" (Nice hairs this morning!)
B: "Vaffanculo!" (fuck you)
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