Anything that can be acted on with confident success.
I'm guessing it originates from the fact that a wheelhouse is the room on the bridge of a ship where you steer from, providing you with clear view & control to steer the situation.
Have the handsome guy address that roomful of female sales potentials; it's right in his wheelhouse.
Singing this song in that key is right in your wheelhouse.
That pitch was thrown down & out, right in the batter's wheelhouse.
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